For acute, uncomplicated cystitis, with mild to moderate symptoms, symptomatic treatment alone may be considered instead of antibiotics after discussion of the options with the patient. Uncomplicated pyelonephritis with a mild to moderate clinical course ought to be treated with oral cefpodoxime, ceftibuten, ciprofloxacin, or levofloxacin. Fluorquinolones and cephalosporins are not recommended. For the treatment of cystitis, fosfomycin-trometamol, nitrofurantoin, nitroxolin, pivmecillinam and trimethoprim are all equally recommended. Results: Symptom-oriented diagnostic evaluation is highly valued. Relevant guidelines were identified in a guideline synopsis. Randomized, controlled trials and systemic reviews were included. A systematic literature search (period: 2008–2015) concerning the diagnosis, treatment, and prevention of uncomplicated urinary tract infections was carried out in the Cochrane Library, MEDLINE, and Embase databases. Methods: The guideline was updated under the aegis of the German Urological Society ( Deutsche Gesellschaft für Urologie). The prevention of recurrent urinary tract infection is considered in this guideline for the first time. This S3 guideline contains recommendations based on current evidence for the rational use of antimicrobial agents and for the prevention of inappropriate use of certain classes of antibiotics and thus of the resulting drug resistance. The resistance level of pathogens has risen markedly. Background: Uncomplicated bacterial community-acquired urinary tract infection is among the more common infections in outpatient practice.
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